2. Signaling Pathways
  3. GPCR/G Protein
  4. TSH Receptor
  5. TSH Receptor Antagonist

TSH Receptor Antagonist

TSH Receptor Antagonists (6):

Cat. No. Product Name Effect Purity
  • HY-12381
    ML224
    		Antagonist 99.18%
    ML224 (NCGC00242364) is a selective TSHR antagonist with an IC50 value of 2.1 µM. ML224 can be used in the study of Graves' disease and other thyroid disorders.
  • HY-153213
    Org 274179-0
    		Antagonist
    Org 274179-0 is a potent and allosteric antagonist of thyroid-stimulating hormone (TSH) receptor, with an IC50 of nanomolar concentration. Org 274179-0 completely inhibits TSH (and TSI)-mediated TSH receptor activation with little effect on the potency of TSH. Org 274179-0 can be used for the research of Graves' disease (GD).
  • HY-129995A
    TSHR antagonist S37a
    		Antagonist 98.00%
    TSHR antagonist S37a is a highly selective thyrotropin receptor (TSHR) antagonist, with potential for the treatment of Graves' orbitopathy.
  • HY-158100
    SYD5115
    		Antagonist 99.69%
    SYD5115 is an orally available TSH-R antagonist.
  • HY-122974
    VA-K-14 hydrochloride
    		Antagonist 98.96%
    VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM).
  • HY-18286
    NCGC00229600
    		Antagonist 99.67%
    NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves' disease.